Fallout 3 Crash after G.O.A.T. Question 3

[patm1987]

I had an issue where the game would crash during the loading screen for a new game, which was solved by uninstalling ASUS Gamer OCD and Smartdoctor. Currently, the game crashes immediately after I answer the third question in G.O.A.T.

Things I have tried:
Installing CCCP then adding fallout 3 to the exceptions list
The quad core fix (enable threaded ai and max hardware threads = 2)
Installing the optional .NET 3.5.1 components
Installing .NET 4.0 (I actually have the SDK)
Upgrading DirectX (I have the June 2010 SDK), yes I do use the SDK's, it was just a matter of time until they were installed
Updated my Audio and Video drivers
I have tried setting the Launcher and Executable to various compatibility settings (it actually makes it crash faster..., still after I answer the question though).
I have verified the integrity of the game cache

Other solutions I've attempted not mentioned anywhere:
Set affinity to two cpu's via the task manager
An issue with Bioshock was resolved by enabling stereo mix in my Sound Menu (I have a Realtek High Definition Audio device)

The relevant system specs:
Windows 7 x64
8gb ram, DDR3
Phenome IIx4
AMD 5870

I am currently on Catalyst 10.5

I have some event logs if they help. This is a new computer (built this past weekend), so I also don't rule out errors during construction (although Fallout3 is the only game not functioning at this moment).

Thanks for your help!

[Evolution']

i solved my issues by running the game in wave audio mode instead of directx audio and i too have a realtek high def onboard soundcard

[patm1987]

Could you provide a brief (where to look at least) and/or a link please? My Google skills are failing me at the moment :-/

Edit: it is an audio issue as I disabled it and got past the crashing section, if you can point me in the right direction i can see disabling DirectX audio would do the trick (I still have my save before the horrible horrible crash).